Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1 		0.300 Biomarker disease RGD Velvet antler peptide prevents pressure overload-induced cardiac fibrosis via transforming growth factor (TGF)-β1 pathway inhibition. 27108788 2016
Entrez Id: 4318
Gene Symbol: MMP9
MMP9 		0.270 Biomarker disease RGD [Effects of xinfeng capsule on myocardial fibrosis in adjuvant arthritis rats and its mechanism research]. 23905389 2013
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1 		0.240 Biomarker disease RGD Involvement of Rho-kinase pathway for angiotensin II-induced plasminogen activator inhibitor-1 gene expression and cardiovascular remodeling in hypertensive rats. 11961044 2002
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1 		0.240 Therapeutic disease RGD Reduced cardiac expression of plasminogen activator inhibitor 1 and transforming growth factor beta1 in obese Zucker rats by perindopril. 15604340 2005
Entrez Id: 1906
Gene Symbol: EDN1
EDN1 		0.230 Therapeutic disease RGD Effects of cilnidipine on nitric oxide and endothelin-1 expression and extracellular signal-regulated kinase in hypertensive rats. 11430925 2001
Entrez Id: 2335
Gene Symbol: FN1
FN1 		0.230 Biomarker disease RGD Losartan prevents heart fibrosis induced by long-term intensive exercise in an animal model. 23383330 2013
Entrez Id: 59272
Gene Symbol: ACE2
ACE2 		0.220 Therapeutic disease RGD Angiotensin-converting enzyme 2 activation protects against hypertension-induced cardiac fibrosis involving extracellular signal-regulated kinases. 21148624 2011
Entrez Id: 1277
Gene Symbol: COL1A1
COL1A1 		0.210 Therapeutic disease RGD A synthetic peptide from transforming growth factor-beta1 type III receptor prevents myocardial fibrosis in spontaneously hypertensive rats. 19019833 2009
Entrez Id: 177
Gene Symbol: AGER
AGER 		0.210 Therapeutic disease RGD Calcitriol modulates receptor for advanced glycation end products (RAGE) in diabetic hearts. 24630381 2014
Entrez Id: 2693
Gene Symbol: GHSR
GHSR 		0.210 Biomarker disease RGD Cardioprotective effects of ghrelin and des-octanoyl ghrelin on myocardial injury induced by isoproterenol in rats. 16626506 2006
Entrez Id: 1277
Gene Symbol: COL1A1
COL1A1 		0.210 Biomarker disease RGD MiR-133a regulates collagen 1A1: potential role of miR-133a in myocardial fibrosis in angiotensin II-dependent hypertension. 21769867 2012
Entrez Id: 177
Gene Symbol: AGER
AGER 		0.210 Biomarker disease RGD Angiotensin II type 1 receptor blocker attenuates diabetes-induced atrial structural remodeling. 21802905 2011
Entrez Id: 2697
Gene Symbol: GJA1
GJA1 		0.210 Biomarker disease RGD [Effects of glutamine induced heat shock protein 70 overexpression on atrial fibrosis and connexin 43 remodeling in isoprenaline-treated rats]. 23906405 2013
Entrez Id: 9927
Gene Symbol: MFN2
MFN2 		0.200 Biomarker disease RGD MicroRNA-214 Mediates Isoproterenol-induced Proliferation and Collagen Synthesis in Cardiac Fibroblasts. 26692091 2015
Entrez Id: 2200
Gene Symbol: FBN1
FBN1 		0.200 Biomarker disease RGD Enhanced expression of fibrillin-1, a constituent of the myocardial extracellular matrix in fibrosis. 15849235 2005
Entrez Id: 51738
Gene Symbol: GHRL
GHRL 		0.200 ModifyingMutation disease RGD Cardioprotective effects of ghrelin and des-octanoyl ghrelin on myocardial injury induced by isoproterenol in rats. 16626506 2006
Entrez Id: 4316
Gene Symbol: MMP7
MMP7 		0.200 Biomarker disease RGD Fibrosis of the left atria during progression of heart failure is associated with increased matrix metalloproteinases in the rat. 12875773 2003
Entrez Id: 144100
Gene Symbol: PLEKHA7
PLEKHA7 		0.200 Biomarker disease RGD Mutation of Plekha7 attenuates salt-sensitive hypertension in the rat. 25136115 2014
Entrez Id: 1756
Gene Symbol: DMD
DMD 		0.200 Biomarker disease RGD Characterization of dystrophin deficient rats: a new model for Duchenne muscular dystrophy. 25310701 2014
Entrez Id: 4792
Gene Symbol: NFKBIA
NFKBIA 		0.200 Therapeutic disease RGD Whole grape intake impacts cardiac peroxisome proliferator-activated receptor and nuclear factor kappaB activity and cytokine expression in rats with diastolic dysfunction. 20231522 2010
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1 		0.300 AlteredExpression disease BEFREE TAC administration induced cardiac fibrosis and heart weight increase, which was associated with the induced expressions of TGF-β1, miR-143-3p, p-Smad2, and collagens. 31758917 2020
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1 		0.300 AlteredExpression disease BEFREE However, anti-TLR2 antibody alleviated masson staining area, levels of TGF-β1 and Collagen I mRNA, and decreased TUNEL-positive myocardial cells and caspase-3 activity, suggesting that anti-TLR2 antibody protected cardiac cells against high-fat-induced cardiac fibrosis and cell apoptosis. 30877771 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1 		0.300 AlteredExpression disease BEFREE This proof-of-concept study using an in vitro experimental cell culture model identifies the protective role of simvastatin against TGF-β1-induced hVF transformation into activated myofibroblasts through activation of protein phosphatase, a novel target that can be therapeutically modulated to curb excessive cardiac fibrosis associated with maladaptive cardiac remodeling. 30220377 2018
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1 		0.300 Biomarker disease BEFREE A recent study reported that deficiency of miR-378a contributes to cardiac fibrosis via TGF-β1-dependent paracrine mechanism. 27855367 2016
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1 		0.300 Biomarker disease BEFREE These data indicate that NE enhances cardiac fibrosis through TGF-beta1 post-receptor signaling, predominantly via the p38 MAP kinase pathway. 12154105 2002